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Tyrphostin AG1433
CAS No. 168835-90-3
Tyrphostin AG1433 ( SU1433 | AG1433 )
产品货号. M26493 CAS No. 168835-90-3
Tyrphostin AG1433 是一种酪氨酸激酶抑制剂，也是 PDGFRβ (IC50s = 5.0 μM) 和 VEGFR-2 (Flk-1/KDR) (IC50s = 9.3 μM) 的双重抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥599 | 有现货 |
|
| 5MG | ￥988 | 有现货 |
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| 10MG | ￥1596 | 有现货 |
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| 25MG | ￥2859 | 有现货 |
|
| 50MG | ￥4358 | 有现货 |
|
| 100MG | ￥6302 | 有现货 |
|
| 500MG | ￥12879 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Tyrphostin AG1433
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Tyrphostin AG1433 是一种酪氨酸激酶抑制剂，也是 PDGFRβ (IC50s = 5.0 μM) 和 VEGFR-2 (Flk-1/KDR) (IC50s = 9.3 μM) 的双重抑制剂。
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产品描述Tyrphostin AG1433 is an inhibitor of tyrosine kinases and also a dual inhibitor of PDGFRβ(IC50s = 5.0 μM) and VEGFR-2 (Flk-1/KDR)(IC50s = 9.3 μM).(In Vitro):In glioblastoma cells, administration of Tyrphostin AG1433 (0.1-100 μM; 72 hours; GB8B cells) induces moderate cytotoxicity .(In Vivo):Tyrphostin AG1433 is prepared in methylcellulose pellets and applies to the CAMs of 4-6-day-old chicken embryos, and prevents the formation of new vessels under the pellets .
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体外实验Tyrphostin AG1433 (0.1-100 μM; 72 hours; GB8B cells) treatment induces moderate cytotoxicity in glioblastoma cells.Cell Viability Assay Cell Line:GB8B cells Concentration:0.1 μM, 1 μM, 5 μM, 10 μM, 20 μM, 30 μM, 50 μM, 60 μM, 100 μM Incubation Time:72 hours Result:Induced significant cell death in GB8B cells in a concentration-dependent manner.
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体内实验Chorion allantoic membrane (CAM) assays are used to determine the effects of the Flk-i inhibitors on angiogenesis. Tyrphostin AG1433 (SU1433) is prepared in methylcellulose pellets and applies to the CAMs of 4-6-day-old chicken embryos. Tyrphostin AG1433 prevents the formation of new yessels under the pellets.
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同义词SU1433 | AG1433
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通路Angiogenesis
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靶点VEGFR
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number168835-90-3
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分子量266.29
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分子式C16H14N2O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 62.5 mg/mL (234.71 mM)
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SMILESOC1=CC=C(C2=NC3=CC(C)=C(C)C=C3N=C2)C=C1O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Shuyun Shi, et al. A high-speed counter-current chromatography- HPLC-DAD method for preparative isolation and purification of two polymethoxylated flavones from Taraxacum mongolicum. J Chromatogr Sc . May-Jun 2009;47(5):349-53.
